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April 2005
Volume 2, Issue 1
MGH Neurosurgical Society Alumni News







Current Issue: [MS Word TM version] [Adobe Acrobat TM version]

Neurosurgery Alumni News MGH Neurosurgical Society Alumni HomePage
William T. Curry cont'd
Continued from page 6

in addition, to its oncolytic properties, is able to stimulate specific and lasting anti-tumor immunity in mice."

The hypothesis of Dr. Curry's group is that pulsing immature dendritic cells with G207-infected tumors cells is a potent activating stimulus for antigen presentation and generation of antitumor immunity, to be demonstrated by vaccine treatment in mice bearing subcutaneous and intracranial Neuro2a tumors. Also, the group proposes that increasing the number of

dendritic cells in tumors, either by coinjection of ex vivo generated cells, or by systemic mobilization from the bone marrow by Flt3L, a growth factor, increases antitumor immunity in the context of oncolytic virus infection. "I became very interested in the antitumor immune response that is provoked by oncolytic herpes virus." said Dr. Curry. "Not only does the virus kill the tumor cells themselves, but also it kicks off an immune response against the tumors. I'm looking at ways of, one, understanding that, and two augmenting the effect."
Dr. Curry is excited and pleased to have won this award, especially in the context of his position at MGH. He said:

"Here, more than any other place, I imagine, I have the opportunity to focus on building an academic neurosurgery career with great mentorship, and also with excellent opportunities for clinical and basic research. I have great role models…the whole environment fosters the development of young investigator-clinicians. In particular, my research is very generously supported by my department and by Dr. Martuza

Neuroscience Series centers on functional , stereotactic
The 2004-5 Neuroscience Series expanded to include the Massachusetts Eye and Ear Departments of Otolaryngology and Opthamology in addition to the MGH departments of Neurosurgery, Neurology and Psychiatry.

The 2004-5 series was organized by Dr. Emad N. Eskandar. Speakers in the Neurosurgery section of the series were Learning and Memory Mechanisms of the Basal Ganglia, Ann Martin Graybiel, PhD Walter A Rosenblith Professor of Neuroscience, Department of Brain and Cognitive Sciences,

Massachusetts Institute of Technology in the Department of Brain and Cognitive Sciences

Computing with Neural Ensembles, Miguel AL Nicolelis, MD, PhD, Professor in the Departments of Neurobiology, Biomedical Engineering and Psychological and Brain Science Co-Director, Center for Neuroengineering at Duke University Medical Center in Durham, North Carolina.

Functional Inhibition of Deep Brain Structures by High Frequency Stimulation: Application to Movement Disorders and other Nervous

Diseases, and Mechanism of Action, Professor Alim Louis Benabid, MD, PhD, Professor at Grenoble University, Neurosurgery and Biophysics, Director of the research laboratory INSERM unit 318, (Preclinical Neurosciences), and has been Head of the Neurosurgery Department at the University Hospital of Grenoble, Professor of Biophysics (exceptional class) at the Joseph Fourier University ;Coordinator Claudio Munari center for surgery of epilepsy and movement disorders, at hospital Ni Guardia, Milan.
Dr. Jeffrey Macklis receives Senator Javits Award

Continued from page 6

somatosensory cortex, which receives tactile information from the body, and the motor cortex, which sends out motor control information to the body. Macklis' findings may lead to the development of cell replacement therapies to treat brain disorders and spinal cord injury.

"This award and extended funding will allow us to continue to take risks in new

directions, especially toward the directed differentiation and functional integration of replacement neurons derived from adult neural precursors, also called 'adult neural stem cells,'" Macklis said.

The $2.8 million award, created in 1983, honors the late U.S. Senator Jacob Javits, who suffered from amyotrophic lateral sclerosis and was an advocate for research on neurological disorders.


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