meets in a weekly conference to review patient care and
treatment options as well as to review cases that were submitted
from outside institutions or physicians for an opinion.
tumors of the brain, we currently belong to the NABTT (New
Approaches to Brain Tumor Therapy) consortium that encompasses
multiple institutions in the Eastern and Southern USA. Through
this consortium, several phase I and II clinical trials
of novel chemotherapy and biologic (gene therapy and immunotoxins)
agents are performed for patients afflicted with malignant
glioma, metastases and lymphoma. In addition, brain tumor
investigator-initiated or company-sponsored clinical trials
are also being performed. For example, a phase I trial for
patients with malignant recurrent glioma using intratumoral
injections of ONYX-015, a replicative tumor-selective adenovirus,
was recently completed.
are being supported not only thorough clinical revenue,
but also through government grants. We were recently awarded
research training fellowship to allow for training of two
neuro-oncologists per year. A multimillion dollar program
project research grant on gene therapy for brain tumors
is in its seventh year of funding. Several basic research
laboratories from BTC clinicians and other collaborators
feed off the clinical expertise available in the center
for research project initiation and completion. Finally,
the generosity of several patients allows for funding of
several research projects.
a vibrant and compassionate collection of experts and ideas
tries to provide the best possible care both in terms of
standard and innovative therapies. The hope is that progress
in treatment is forthcoming for some of these tumors, which
are currently so difficult to treat.
Brem was awarded Physician of the Year by the H. Lee Moffitt
Cancer & Research Center in Tampa, Florida.
H. Chapman, chief of pediatric neurosurgery at the MGH,
was named the first Nicholas T. Zervas Professor in Neurosurgery
at Harvard Medical School. The Zervas Chair was awarded
to former chief of MGH Neurosurgery, Nicholas T. Zervas.
which is to be held by a faculty member in the MGH Neurosurgery
Department, honors Dr. Zervas' dedication and many contributions
to the field of neurosurgery.
Ghogawala is coordinating with Lawrence Borges and Edward
Benzel a national multi-center clinical trial looking at
fusion versus no fusion for patients with symptomatic spinal
stenosis with a grade I spondylolisthesis.
Heros completed his term as President of the American
Association of Neurological Surgeons.
Lavyne has been appointed Professor of Clinical Neurosurgery
by the Weill Medical College of Cornell University.
Onofrio has been appointed Professor Chair at the Mayo
Wilkinson recently retired from surgery, but will continue
a limited consultative practice at MGH and Newton-Wellesley
Hospital's Spine Clinic.